MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
Comblib matrices | 14 | 16 | 11 |
Consensus IEDB method | 48 | 48 | 48 |
NN-align | 57 | 61 | 53 |
NN-align 2.3 | 59 | 54 | 64 |
NetMHCIIpan-3.1 | 53 | 55 | 52 |
NetMHCIIpan-3.2 | 61 | 59 | 63 |
NetMHCIIpan-4.0 BA | 71 | 71 | 71 |
NetMHCIIpan-4.0 EL | 29 | 29 | 29 |
NetMHCIIpan-4.1 BA | 75 | 75 | 74 |
NetMHCIIpan-4.1 EL | 28 | 28 | 29 |
NetMHCIIpan-4.2 BA | 82 | 80 | 83 |
NetMHCIIpan-4.2 EL | 35 | 33 | 37 |
NetMHCIIpan-4.3 BA | 77 | 74 | 79 |
NetMHCIIpan-4.3 EL | 29 | 29 | 30 |
SMM-align | 35 | 38 | 31 |
Tepitope (Sturniolo) | 28 | 27 | 29 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
1042786 | HLA-DRB1*01:01 | 26 | 4 | ic50 | 0.100 | 0.614 | 0.236 | 0.591 | 0.475 | 0.727 | 0.245 | 0.727 | 0.331 | 0.659 | 0.433 | 0.716 | 0.422 | 0.705 | 0.453 | 0.886 | 0.408 | 0.693 | 0.479 | 0.909 | 0.408 | 0.693 | 0.514 | 0.932 | 0.363 | 0.739 | 0.496 | 0.864 | 0.480 | 0.636 | 0.500 | 0.648 |
1043121 | HLA-DRB1*01:01 | 89 | 28 | binary | 0.627 | 0.890 | 0.621 | 0.888 | 0.642 | 0.899 | 0.637 | 0.896 | 0.666 | 0.914 | 0.665 | 0.913 | 0.653 | 0.906 | 0.302 | 0.695 | 0.656 | 0.908 | 0.319 | 0.708 | 0.663 | 0.912 | 0.302 | 0.694 | 0.648 | 0.903 | 0.291 | 0.684 | 0.572 | 0.858 | 0.448 | 0.792 |
1043121 | HLA-DRB1*03:01 | 89 | 6 | binary | - | - | 0.369 | 0.939 | 0.389 | 0.948 | 0.363 | 0.918 | 0.419 | 0.982 | 0.412 | 0.974 | 0.385 | 0.944 | 0.229 | 0.765 | 0.392 | 0.952 | 0.244 | 0.781 | 0.391 | 0.950 | 0.238 | 0.774 | 0.410 | 0.972 | 0.255 | 0.791 | 0.346 | 0.898 | 0.281 | 0.840 |
1043121 | HLA-DRB1*04:01 | 89 | 27 | binary | - | - | 0.598 | 0.879 | 0.553 | 0.847 | 0.544 | 0.842 | 0.545 | 0.842 | 0.531 | 0.833 | 0.511 | 0.821 | 0.280 | 0.688 | 0.499 | 0.813 | 0.260 | 0.668 | 0.534 | 0.835 | 0.299 | 0.693 | 0.550 | 0.845 | 0.278 | 0.678 | 0.518 | 0.826 | 0.619 | 0.892 |
1043121 | HLA-DRB1*07:01 | 89 | 26 | binary | 0.550 | 0.849 | 0.678 | 0.935 | 0.617 | 0.892 | 0.692 | 0.939 | 0.706 | 0.948 | 0.700 | 0.944 | 0.712 | 0.952 | 0.438 | 0.785 | 0.713 | 0.952 | 0.388 | 0.748 | 0.725 | 0.960 | 0.426 | 0.773 | 0.728 | 0.962 | 0.398 | 0.755 | 0.622 | 0.895 | 0.642 | 0.918 |
1043570 | HLA-DRB1*15:01 | 146 | 13 | binary | - | - | 0.357 | 0.867 | 0.377 | 0.882 | 0.370 | 0.875 | 0.366 | 0.871 | 0.378 | 0.883 | 0.375 | 0.880 | 0.249 | 0.763 | 0.374 | 0.879 | 0.263 | 0.770 | 0.379 | 0.884 | 0.267 | 0.780 | 0.375 | 0.880 | 0.244 | 0.758 | 0.314 | 0.818 | 0.322 | 0.848 |
1043728 | HLA-DRB1*01:01 | 16 | 8 | binary | -0.027 | 0.484 | 0.204 | 0.617 | 0.136 | 0.578 | -0.108 | 0.438 | 0.081 | 0.547 | -0.081 | 0.453 | 0.081 | 0.547 | 0.217 | 0.625 | -0.027 | 0.484 | 0.217 | 0.625 | 0.108 | 0.562 | 0.244 | 0.641 | -0.054 | 0.469 | 0.244 | 0.641 | 0.353 | 0.703 | 0.190 | 0.609 |
1043728 | HLA-DRB1*03:01 | 13 | 4 | binary | - | - | 0.335 | 0.708 | 0.178 | 0.611 | 0.134 | 0.583 | 0.312 | 0.694 | 0.312 | 0.694 | 0.445 | 0.778 | 0.223 | 0.639 | 0.356 | 0.722 | 0.223 | 0.639 | 0.267 | 0.667 | 0.178 | 0.611 | 0.356 | 0.722 | 0.089 | 0.556 | 0.401 | 0.750 | -0.134 | 0.417 |
1043728 | HLA-DRB1*04:01 | 17 | 10 | binary | - | - | 0.415 | 0.771 | 0.537 | 0.814 | 0.317 | 0.686 | 0.464 | 0.771 | 0.390 | 0.729 | 0.464 | 0.771 | 0.610 | 0.857 | 0.488 | 0.786 | 0.610 | 0.857 | 0.512 | 0.800 | 0.598 | 0.879 | 0.634 | 0.871 | 0.537 | 0.814 | 0.488 | 0.786 | 0.342 | 0.700 |
1043728 | HLA-DRB1*15:01 | 13 | 10 | binary | - | - | 0.244 | 0.667 | 0.244 | 0.667 | 0.244 | 0.667 | 0.293 | 0.700 | 0.195 | 0.633 | 0.293 | 0.700 | 0.000 | 0.500 | 0.293 | 0.700 | 0.146 | 0.600 | 0.390 | 0.767 | 0.293 | 0.700 | 0.293 | 0.700 | 0.244 | 0.667 | -0.049 | 0.467 | 0.489 | 0.833 |
1044682 | HLA-DPA1*01:03/DPB1*02:01 | 46 | 14 | ic50 | 0.421 | 0.747 | 0.642 | 0.809 | 0.702 | 0.839 | 0.705 | 0.862 | 0.709 | 0.844 | 0.785 | 0.891 | 0.779 | 0.871 | 0.451 | 0.737 | 0.815 | 0.875 | 0.462 | 0.734 | 0.791 | 0.886 | 0.445 | 0.781 | 0.754 | 0.862 | 0.387 | 0.733 | 0.661 | 0.812 | - | - |
1044682 | HLA-DPA1*01:03/DPB1*03:01 | 46 | 16 | ic50 | - | - | - | - | - | - | 0.580 | 0.804 | 0.011 | 0.479 | 0.507 | 0.752 | 0.605 | 0.852 | 0.450 | 0.808 | 0.660 | 0.867 | 0.448 | 0.810 | 0.645 | 0.871 | 0.441 | 0.802 | 0.620 | 0.869 | 0.507 | 0.819 | - | - | - | - |
1044682 | HLA-DPA1*01:03/DPB1*04:01 | 46 | 13 | ic50 | - | - | - | - | - | - | 0.664 | 0.823 | 0.613 | 0.804 | 0.708 | 0.858 | 0.737 | 0.862 | 0.428 | 0.742 | 0.761 | 0.883 | 0.447 | 0.789 | 0.732 | 0.869 | 0.413 | 0.767 | 0.678 | 0.828 | 0.351 | 0.762 | - | - | - | - |
1044682 | HLA-DPA1*02:01/DPB1*05:01 | 46 | 2 | ic50 | 0.235 | 0.375 | 0.639 | 0.676 | 0.759 | 0.830 | 0.624 | 0.852 | 0.694 | 0.750 | 0.610 | 0.773 | 0.616 | 0.761 | 0.156 | 0.807 | 0.597 | 0.795 | 0.078 | 0.824 | 0.602 | 0.818 | 0.021 | 0.625 | 0.571 | 0.852 | 0.043 | 0.716 | 0.704 | 0.670 | - | - |
1044682 | HLA-DPA1*02:01/DPB1*14:01 | 46 | 12 | ic50 | - | - | - | - | - | - | 0.603 | 0.885 | 0.261 | 0.571 | 0.531 | 0.809 | 0.607 | 0.836 | 0.385 | 0.767 | 0.642 | 0.858 | 0.362 | 0.745 | 0.668 | 0.877 | 0.314 | 0.761 | 0.615 | 0.826 | 0.561 | 0.853 | - | - | - | - |
1044682 | HLA-DPA1*03:01/DPB1*04:02 | 46 | 15 | ic50 | 0.594 | 0.832 | 0.713 | 0.886 | 0.703 | 0.849 | 0.560 | 0.811 | 0.689 | 0.841 | 0.719 | 0.860 | 0.765 | 0.886 | 0.249 | 0.629 | 0.779 | 0.888 | 0.310 | 0.673 | 0.738 | 0.862 | 0.257 | 0.637 | 0.697 | 0.858 | 0.196 | 0.638 | 0.684 | 0.845 | - | - |
1044682 | HLA-DQA1*01:01/DQB1*05:01 | 46 | 8 | ic50 | 0.078 | 0.635 | 0.136 | 0.727 | 0.151 | 0.743 | 0.004 | 0.707 | 0.124 | 0.678 | 0.101 | 0.747 | 0.161 | 0.812 | -0.010 | 0.684 | 0.138 | 0.789 | -0.005 | 0.651 | 0.140 | 0.799 | 0.072 | 0.709 | 0.122 | 0.809 | -0.018 | 0.643 | 0.238 | 0.697 | - | - |
1044682 | HLA-DQA1*03:01/DQB1*03:02 | 46 | 6 | ic50 | 0.132 | 0.550 | 0.451 | 0.825 | 0.551 | 0.904 | 0.444 | 0.950 | 0.582 | 0.925 | 0.511 | 0.942 | 0.560 | 0.975 | 0.363 | 0.831 | 0.564 | 0.963 | 0.455 | 0.854 | 0.558 | 0.963 | 0.398 | 0.842 | 0.521 | 0.967 | 0.382 | 0.833 | 0.516 | 0.800 | - | - |
1044682 | HLA-DQA1*05:01/DQB1*02:01 | 46 | 18 | ic50 | 0.399 | 0.666 | 0.587 | 0.781 | 0.645 | 0.813 | 0.526 | 0.813 | 0.596 | 0.808 | 0.554 | 0.827 | 0.537 | 0.849 | 0.315 | 0.719 | 0.541 | 0.843 | 0.366 | 0.740 | 0.582 | 0.853 | 0.368 | 0.739 | 0.617 | 0.875 | 0.357 | 0.727 | 0.574 | 0.758 | - | - |
1044682 | HLA-DQA1*05:01/DQB1*03:01 | 46 | 7 | ic50 | 0.509 | 0.668 | 0.683 | 0.853 | 0.600 | 0.817 | 0.597 | 0.850 | 0.665 | 0.864 | 0.643 | 0.879 | 0.692 | 0.916 | 0.377 | 0.804 | 0.712 | 0.927 | 0.371 | 0.810 | 0.699 | 0.938 | 0.300 | 0.786 | 0.698 | 0.923 | 0.319 | 0.766 | 0.679 | 0.868 | - | - |
1044682 | HLA-DRB1*01:01 | 49 | 22 | ic50 | 0.321 | 0.704 | 0.581 | 0.840 | 0.709 | 0.899 | 0.801 | 0.940 | 0.814 | 0.963 | 0.842 | 0.966 | 0.848 | 0.965 | 0.613 | 0.811 | 0.863 | 0.965 | 0.606 | 0.803 | 0.864 | 0.968 | 0.621 | 0.811 | 0.834 | 0.956 | 0.608 | 0.803 | 0.539 | 0.815 | 0.478 | 0.768 |
1044682 | HLA-DRB1*03:01 | 46 | 3 | ic50 | - | - | 0.476 | 0.853 | 0.593 | 0.891 | 0.550 | 0.845 | 0.510 | 0.915 | 0.534 | 0.907 | 0.514 | 0.884 | 0.571 | 0.783 | 0.517 | 0.907 | 0.547 | 0.783 | 0.492 | 0.899 | 0.567 | 0.798 | 0.529 | 0.884 | 0.576 | 0.798 | 0.432 | 0.822 | 0.231 | 0.907 |
1044682 | HLA-DRB1*04:01 | 116 | 32 | ic50 | - | - | 0.657 | 0.881 | 0.598 | 0.842 | 0.718 | 0.941 | 0.634 | 0.884 | 0.658 | 0.898 | 0.687 | 0.923 | 0.534 | 0.881 | 0.707 | 0.924 | 0.542 | 0.876 | 0.717 | 0.941 | 0.542 | 0.894 | 0.706 | 0.930 | 0.539 | 0.892 | 0.538 | 0.790 | 0.504 | 0.779 |
1044682 | HLA-DRB1*04:05 | 116 | 38 | ic50 | - | - | 0.512 | 0.775 | 0.566 | 0.824 | 0.665 | 0.856 | 0.576 | 0.790 | 0.644 | 0.810 | 0.665 | 0.838 | 0.471 | 0.782 | 0.674 | 0.844 | 0.462 | 0.784 | 0.708 | 0.865 | 0.469 | 0.794 | 0.695 | 0.856 | 0.487 | 0.795 | 0.375 | 0.707 | 0.422 | 0.706 |
1044682 | HLA-DRB1*07:01 | 49 | 32 | ic50 | 0.270 | 0.631 | 0.514 | 0.753 | 0.566 | 0.801 | 0.678 | 0.842 | 0.572 | 0.754 | 0.694 | 0.831 | 0.701 | 0.844 | 0.459 | 0.732 | 0.701 | 0.840 | 0.439 | 0.743 | 0.761 | 0.873 | 0.466 | 0.767 | 0.748 | 0.864 | 0.487 | 0.752 | 0.412 | 0.682 | 0.356 | 0.627 |
1044682 | HLA-DRB1*08:02 | 46 | 8 | ic50 | - | - | 0.417 | 0.806 | 0.521 | 0.717 | 0.507 | 0.717 | 0.666 | 0.826 | 0.641 | 0.822 | 0.714 | 0.865 | 0.568 | 0.757 | 0.749 | 0.859 | - | - | 0.785 | 0.895 | 0.581 | 0.707 | 0.724 | 0.859 | 0.571 | 0.688 | 0.136 | 0.691 | 0.445 | 0.814 |
1044682 | HLA-DRB1*09:01 | 46 | 27 | ic50 | 0.277 | 0.674 | 0.677 | 0.868 | 0.438 | 0.752 | 0.620 | 0.840 | 0.474 | 0.762 | 0.621 | 0.821 | 0.581 | 0.788 | 0.470 | 0.735 | 0.577 | 0.797 | 0.431 | 0.729 | 0.615 | 0.812 | 0.420 | 0.710 | 0.635 | 0.840 | 0.399 | 0.714 | 0.297 | 0.645 | - | - |
1044682 | HLA-DRB1*11:01 | 46 | 16 | ic50 | - | - | 0.562 | 0.772 | 0.756 | 0.854 | 0.824 | 0.908 | 0.704 | 0.840 | 0.728 | 0.858 | 0.789 | 0.887 | 0.611 | 0.777 | 0.770 | 0.865 | 0.585 | 0.760 | 0.777 | 0.871 | 0.594 | 0.765 | 0.756 | 0.863 | 0.602 | 0.758 | 0.551 | 0.762 | 0.289 | 0.604 |
1044682 | HLA-DRB1*12:01 | 46 | 11 | ic50 | - | - | 0.640 | 0.897 | - | - | 0.734 | 0.922 | 0.479 | 0.777 | 0.787 | 0.919 | 0.760 | 0.899 | 0.478 | 0.870 | 0.753 | 0.896 | 0.445 | 0.855 | 0.803 | 0.925 | 0.496 | 0.894 | 0.821 | 0.940 | 0.495 | 0.883 | 0.227 | 0.634 | - | - |
1044682 | HLA-DRB1*13:02 | 46 | 5 | ic50 | - | - | 0.548 | 0.932 | 0.644 | 0.915 | 0.736 | 0.976 | 0.777 | 0.995 | 0.744 | 0.985 | 0.720 | 0.976 | 0.499 | 0.795 | 0.719 | 0.971 | 0.414 | 0.741 | 0.735 | 0.976 | 0.380 | 0.746 | 0.754 | 0.985 | 0.291 | 0.695 | 0.367 | 0.917 | 0.130 | 0.639 |
1044682 | HLA-DRB1*15:01 | 116 | 65 | ic50 | - | - | 0.581 | 0.771 | 0.553 | 0.769 | 0.636 | 0.815 | 0.553 | 0.767 | 0.617 | 0.805 | 0.694 | 0.842 | 0.572 | 0.785 | 0.690 | 0.844 | 0.519 | 0.760 | 0.701 | 0.854 | 0.517 | 0.754 | 0.652 | 0.823 | 0.500 | 0.741 | 0.589 | 0.792 | 0.407 | 0.664 |
1044682 | HLA-DRB3*01:01 | 46 | 5 | ic50 | 0.005 | 0.756 | 0.447 | 0.980 | 0.537 | 0.971 | 0.503 | 1.000 | 0.446 | 1.000 | 0.490 | 1.000 | 0.517 | 1.000 | 0.320 | 0.995 | 0.536 | 1.000 | 0.258 | 0.995 | 0.599 | 1.000 | 0.284 | 1.000 | 0.573 | 1.000 | 0.313 | 1.000 | 0.518 | 0.966 | - | - |
1044682 | HLA-DRB3*02:02 | 46 | 12 | ic50 | - | - | - | - | - | - | 0.800 | 0.951 | 0.707 | 0.819 | 0.786 | 0.917 | 0.820 | 0.914 | 0.540 | 0.880 | 0.826 | 0.926 | 0.554 | 0.873 | 0.829 | 0.917 | 0.622 | 0.926 | 0.808 | 0.914 | 0.638 | 0.917 | - | - | - | - |
1044682 | HLA-DRB4*01:01 | 49 | 9 | ic50 | 0.046 | 0.594 | 0.442 | 0.951 | 0.580 | 0.961 | 0.674 | 0.989 | 0.506 | 0.886 | 0.435 | 0.761 | 0.536 | 0.875 | 0.544 | 0.844 | 0.561 | 0.878 | 0.580 | 0.894 | 0.571 | 0.908 | 0.611 | 0.875 | 0.569 | 0.903 | 0.603 | 0.869 | 0.283 | 0.864 | - | - |
1044682 | HLA-DRB5*01:01 | 49 | 27 | ic50 | - | - | 0.522 | 0.769 | 0.535 | 0.747 | 0.737 | 0.897 | 0.727 | 0.848 | 0.711 | 0.867 | 0.767 | 0.886 | 0.555 | 0.758 | 0.780 | 0.894 | 0.488 | 0.733 | 0.778 | 0.896 | 0.507 | 0.745 | 0.760 | 0.896 | 0.502 | 0.751 | 0.477 | 0.740 | 0.468 | 0.711 |