MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
Comblib matrices | 12 | 10 | 14 |
Consensus IEDB method | 56 | 58 | 54 |
NN-align | 42 | 38 | 45 |
NN-align 2.3 | 58 | 60 | 56 |
NetMHCIIpan-3.1 | 52 | 49 | 55 |
NetMHCIIpan-3.2 | 64 | 62 | 66 |
NetMHCIIpan-4.0 BA | 78 | 76 | 81 |
NetMHCIIpan-4.0 EL | 24 | 21 | 26 |
NetMHCIIpan-4.1 BA | 82 | 80 | 84 |
NetMHCIIpan-4.1 EL | 39 | 38 | 40 |
NetMHCIIpan-4.2 BA | 74 | 71 | 77 |
NetMHCIIpan-4.2 EL | 38 | 36 | 40 |
NetMHCIIpan-4.3 BA | 69 | 69 | 69 |
NetMHCIIpan-4.3 EL | 35 | 35 | 36 |
SMM-align | 43 | 47 | 38 |
Tepitope (Sturniolo) | 30 | 22 | 38 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
1041296 | HLA-DRB1*01:01 | 14 | 4 | ic50 | 0.511 | 0.700 | 0.880 | 0.962 | 0.748 | 0.950 | 0.869 | 1.000 | 0.766 | 0.875 | 0.829 | 0.925 | 0.807 | 0.900 | 0.689 | 0.800 | 0.785 | 0.875 | 0.675 | 0.775 | 0.812 | 0.875 | 0.774 | 0.825 | 0.752 | 0.825 | 0.744 | 0.850 | 0.812 | 0.875 | 0.441 | 0.825 |
1041296 | HLA-DRB1*04:01 | 14 | 4 | ic50 | - | - | 0.064 | 0.500 | 0.231 | 0.625 | -0.037 | 0.500 | 0.240 | 0.675 | 0.191 | 0.675 | 0.064 | 0.550 | -0.359 | 0.363 | 0.095 | 0.550 | -0.143 | 0.400 | 0.033 | 0.575 | -0.095 | 0.450 | 0.055 | 0.575 | -0.262 | 0.325 | 0.046 | 0.500 | 0.196 | 0.550 |
1041296 | HLA-DRB1*04:05 | 14 | 2 | ic50 | - | - | 0.508 | 0.583 | 0.741 | 0.875 | 0.684 | 0.833 | 0.248 | 0.542 | 0.248 | 0.583 | 0.218 | 0.500 | 0.125 | 0.583 | 0.262 | 0.542 | 0.297 | 0.708 | 0.209 | 0.583 | 0.266 | 0.812 | 0.402 | 0.542 | 0.341 | 0.708 | 0.490 | 0.583 | 0.442 | 0.667 |
1041296 | HLA-DRB1*07:01 | 14 | 6 | ic50 | 0.423 | 0.625 | 0.735 | 0.833 | 0.829 | 0.958 | 0.748 | 0.875 | 0.761 | 0.875 | 0.834 | 0.938 | 0.858 | 0.958 | 0.783 | 0.812 | 0.827 | 0.917 | 0.715 | 0.792 | 0.860 | 0.938 | 0.803 | 0.833 | 0.867 | 0.938 | 0.680 | 0.771 | 0.849 | 0.917 | 0.660 | 0.833 |
1041296 | HLA-DRB1*08:02 | 14 | 4 | ic50 | - | - | 0.644 | 0.900 | 0.341 | 0.750 | 0.493 | 0.800 | 0.728 | 0.950 | 0.686 | 0.900 | 0.708 | 0.950 | 0.598 | 0.900 | 0.746 | 0.975 | 0.735 | 0.925 | 0.711 | 0.950 | 0.640 | 0.875 | 0.741 | 0.975 | 0.744 | 0.875 | 0.381 | 0.700 | 0.572 | 0.800 |
1041296 | HLA-DRB1*09:01 | 14 | 8 | ic50 | -0.118 | 0.500 | 0.562 | 0.875 | 0.453 | 0.833 | 0.656 | 0.958 | 0.592 | 0.875 | 0.614 | 0.896 | 0.737 | 0.958 | 0.596 | 0.938 | 0.748 | 0.979 | 0.704 | 0.979 | 0.724 | 0.958 | 0.678 | 0.958 | 0.645 | 0.938 | 0.642 | 0.958 | 0.695 | 0.875 | - | - |
1041296 | HLA-DRB1*11:01 | 14 | 8 | ic50 | - | - | 0.764 | 0.875 | 0.793 | 0.854 | 0.837 | 0.875 | 0.758 | 0.875 | 0.807 | 0.896 | 0.807 | 0.896 | 0.604 | 0.688 | 0.776 | 0.875 | 0.670 | 0.729 | 0.793 | 0.896 | 0.688 | 0.729 | 0.833 | 0.896 | 0.684 | 0.729 | 0.722 | 0.792 | 0.726 | 0.896 |
1041296 | HLA-DRB1*12:01 | 14 | 4 | ic50 | - | - | 0.675 | 0.912 | - | - | 0.666 | 0.850 | 0.600 | 0.850 | 0.653 | 0.850 | 0.727 | 0.875 | 0.481 | 0.750 | 0.670 | 0.875 | 0.385 | 0.775 | 0.723 | 0.875 | 0.284 | 0.688 | 0.697 | 0.875 | 0.473 | 0.825 | 0.600 | 0.800 | - | - |
1041296 | HLA-DRB1*15:01 | 14 | 6 | ic50 | - | - | 0.868 | 0.958 | 0.662 | 0.979 | 0.780 | 0.938 | 0.785 | 1.000 | 0.815 | 0.979 | 0.873 | 1.000 | 0.490 | 0.667 | 0.864 | 1.000 | 0.512 | 0.667 | 0.776 | 0.938 | 0.481 | 0.667 | 0.785 | 0.958 | 0.495 | 0.688 | 0.626 | 0.833 | 0.861 | 0.948 |
1041814 | HLA-DRB1*04:01 | 122 | 13 | ic50 | - | - | 0.387 | 0.777 | 0.383 | 0.783 | 0.391 | 0.745 | 0.427 | 0.782 | 0.435 | 0.788 | 0.442 | 0.821 | 0.332 | 0.783 | 0.446 | 0.822 | 0.337 | 0.771 | 0.443 | 0.818 | 0.339 | 0.773 | 0.461 | 0.817 | 0.356 | 0.794 | 0.398 | 0.778 | 0.346 | 0.802 |
1041880 | HLA-DRB1*03:01 | 98 | 55 | binary | - | - | 0.111 | 0.567 | 0.083 | 0.548 | 0.068 | 0.540 | 0.201 | 0.617 | 0.099 | 0.558 | 0.136 | 0.579 | 0.018 | 0.511 | 0.165 | 0.596 | -0.015 | 0.492 | 0.192 | 0.611 | -0.027 | 0.486 | 0.134 | 0.578 | -0.012 | 0.494 | 0.076 | 0.544 | 0.254 | 0.649 |
1041880 | HLA-DRB1*07:01 | 98 | 50 | binary | 0.253 | 0.646 | 0.157 | 0.594 | 0.170 | 0.598 | 0.172 | 0.599 | 0.243 | 0.640 | 0.198 | 0.614 | 0.176 | 0.602 | -0.008 | 0.495 | 0.181 | 0.605 | -0.068 | 0.461 | 0.178 | 0.603 | -0.081 | 0.454 | 0.193 | 0.612 | -0.056 | 0.469 | 0.137 | 0.580 | 0.128 | 0.575 |
1041880 | HLA-DRB1*09:01 | 98 | 53 | binary | 0.147 | 0.587 | 0.141 | 0.583 | 0.077 | 0.545 | 0.138 | 0.580 | 0.136 | 0.579 | 0.154 | 0.589 | 0.152 | 0.588 | -0.016 | 0.491 | 0.145 | 0.584 | -0.109 | 0.437 | 0.160 | 0.593 | -0.115 | 0.434 | 0.149 | 0.586 | -0.093 | 0.446 | 0.052 | 0.531 | - | - |
1041880 | HLA-DRB1*15:01 | 98 | 53 | binary | - | - | 0.208 | 0.622 | 0.227 | 0.631 | 0.200 | 0.616 | 0.265 | 0.654 | 0.234 | 0.636 | 0.281 | 0.663 | 0.175 | 0.602 | 0.286 | 0.665 | 0.141 | 0.582 | 0.268 | 0.655 | 0.178 | 0.605 | 0.239 | 0.639 | 0.162 | 0.594 | 0.246 | 0.643 | 0.198 | 0.619 |
1042193 | HLA-DRB1*08:03 | 26 | 16 | binary | - | - | - | - | - | - | - | - | 0.137 | 0.581 | 0.053 | 0.531 | 0.126 | 0.575 | 0.464 | 0.775 | 0.137 | 0.581 | 0.517 | 0.806 | 0.116 | 0.569 | 0.464 | 0.775 | 0.105 | 0.562 | 0.422 | 0.750 | - | - | - | - |
1042193 | HLA-DRB1*11:01 | 26 | 18 | binary | - | - | 0.545 | 0.840 | 0.322 | 0.701 | 0.622 | 0.889 | 0.622 | 0.889 | 0.578 | 0.861 | 0.578 | 0.861 | 0.489 | 0.806 | 0.589 | 0.868 | 0.500 | 0.812 | 0.578 | 0.861 | 0.478 | 0.799 | 0.567 | 0.854 | 0.556 | 0.847 | 0.444 | 0.778 | 0.334 | 0.708 |
1042693 | HLA-DRB1*01:01 | 14 | 6 | ic50 | 0.493 | 0.667 | 0.623 | 0.948 | 0.486 | 0.896 | 0.314 | 0.812 | 0.547 | 0.917 | 0.556 | 0.875 | 0.626 | 0.896 | 0.429 | 0.646 | 0.613 | 0.896 | 0.486 | 0.667 | 0.604 | 0.875 | 0.543 | 0.646 | 0.569 | 0.875 | 0.560 | 0.646 | 0.569 | 0.833 | 0.095 | 0.583 |
1042693 | HLA-DRB1*04:01 | 14 | 6 | ic50 | - | - | 0.613 | 0.958 | 0.648 | 0.896 | 0.613 | 0.958 | 0.653 | 0.917 | 0.622 | 0.958 | 0.710 | 1.000 | 0.420 | 0.750 | 0.719 | 1.000 | 0.490 | 0.792 | 0.701 | 1.000 | 0.534 | 0.833 | 0.697 | 1.000 | 0.433 | 0.771 | 0.600 | 0.917 | 0.439 | 0.854 |
1042693 | HLA-DRB1*04:05 | 11 | 6 | ic50 | - | - | 0.562 | 0.917 | 0.473 | 0.767 | 0.464 | 0.767 | 0.418 | 0.833 | 0.536 | 0.900 | 0.691 | 0.967 | 0.555 | 0.833 | 0.709 | 0.967 | 0.591 | 0.867 | 0.700 | 0.967 | 0.518 | 0.833 | 0.536 | 0.900 | 0.500 | 0.867 | 0.382 | 0.800 | 0.496 | 0.800 |
1042693 | HLA-DRB1*07:01 | 13 | 8 | ic50 | 0.358 | 0.725 | 0.484 | 0.700 | 0.280 | 0.500 | 0.599 | 0.800 | 0.330 | 0.600 | 0.505 | 0.775 | 0.555 | 0.800 | 0.429 | 0.625 | 0.555 | 0.800 | 0.418 | 0.625 | 0.555 | 0.800 | 0.434 | 0.625 | 0.516 | 0.775 | 0.432 | 0.625 | 0.505 | 0.750 | 0.328 | 0.575 |
1042693 | HLA-DRB1*08:02 | 12 | 5 | ic50 | - | - | 0.592 | 0.743 | 0.580 | 0.714 | 0.608 | 0.743 | 0.476 | 0.686 | 0.657 | 0.886 | 0.497 | 0.743 | -0.028 | 0.486 | 0.524 | 0.743 | 0.063 | 0.486 | 0.497 | 0.743 | 0.035 | 0.486 | 0.566 | 0.743 | 0.000 | 0.429 | 0.510 | 0.771 | 0.221 | 0.600 |
1042693 | HLA-DRB1*09:01 | 14 | 8 | ic50 | 0.165 | 0.385 | 0.365 | 0.521 | 0.305 | 0.542 | 0.310 | 0.542 | 0.429 | 0.583 | 0.433 | 0.604 | 0.547 | 0.708 | 0.218 | 0.562 | 0.666 | 0.771 | 0.574 | 0.771 | 0.538 | 0.708 | 0.604 | 0.792 | 0.455 | 0.604 | 0.582 | 0.771 | 0.196 | 0.500 | - | - |
1042693 | HLA-DRB1*11:01 | 14 | 9 | ic50 | - | - | 0.697 | 0.822 | 0.640 | 0.844 | 0.710 | 0.844 | 0.644 | 0.800 | 0.723 | 0.867 | 0.701 | 0.889 | 0.327 | 0.689 | 0.679 | 0.889 | 0.538 | 0.844 | 0.604 | 0.844 | 0.591 | 0.867 | 0.626 | 0.822 | 0.356 | 0.756 | 0.736 | 0.822 | 0.313 | 0.733 |
1042693 | HLA-DRB1*12:01 | 12 | 3 | ic50 | - | - | 0.664 | 0.815 | - | - | 0.762 | 0.926 | 0.657 | 0.815 | 0.699 | 0.852 | 0.678 | 0.852 | 0.224 | 0.593 | 0.748 | 0.889 | 0.420 | 0.741 | 0.755 | 0.889 | 0.151 | 0.648 | 0.825 | 0.926 | 0.063 | 0.519 | 0.364 | 0.593 | - | - |
1042693 | HLA-DRB1*15:01 | 14 | 5 | ic50 | - | - | 0.336 | 0.644 | 0.319 | 0.667 | 0.345 | 0.600 | 0.437 | 0.733 | 0.477 | 0.733 | 0.477 | 0.733 | 0.112 | 0.489 | 0.512 | 0.756 | 0.477 | 0.711 | 0.512 | 0.756 | 0.345 | 0.667 | 0.503 | 0.778 | 0.420 | 0.656 | 0.305 | 0.622 | 0.258 | 0.800 |