MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
Comblib matrices | 5 | 5 | 5 |
Consensus IEDB method | 55 | 56 | 55 |
NN-align | 40 | 38 | 43 |
NN-align 2.3 | 47 | 48 | 46 |
NetMHCIIpan-3.1 | 54 | 50 | 58 |
NetMHCIIpan-3.2 | 59 | 55 | 62 |
NetMHCIIpan-4.0 BA | 65 | 62 | 67 |
NetMHCIIpan-4.0 EL | 49 | 48 | 50 |
NetMHCIIpan-4.1 BA | 67 | 64 | 70 |
NetMHCIIpan-4.1 EL | 54 | 53 | 56 |
NetMHCIIpan-4.2 BA | 70 | 66 | 74 |
NetMHCIIpan-4.2 EL | 57 | 55 | 60 |
NetMHCIIpan-4.3 BA | 72 | 72 | 72 |
NetMHCIIpan-4.3 EL | 52 | 51 | 54 |
SMM-align | 47 | 49 | 46 |
Tepitope (Sturniolo) | 39 | 37 | 42 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
1040638 | HLA-DRB1*04:01 | 21 | 2 | ic50 | - | - | 0.591 | 0.605 | 0.449 | 0.526 | 0.367 | 0.474 | 0.545 | 0.763 | 0.463 | 0.737 | 0.509 | 0.737 | 0.357 | 0.605 | 0.493 | 0.737 | 0.285 | 0.553 | 0.538 | 0.737 | 0.318 | 0.776 | 0.514 | 0.658 | 0.337 | 0.526 | 0.609 | 0.605 | 0.435 | 0.605 |
1041090 | HLA-DRB1*04:01 | 24 | 9 | ic50 | - | - | 0.270 | 0.633 | 0.338 | 0.696 | 0.240 | 0.622 | 0.173 | 0.659 | 0.245 | 0.659 | 0.323 | 0.726 | 0.527 | 0.763 | 0.367 | 0.748 | 0.462 | 0.741 | 0.409 | 0.756 | 0.469 | 0.726 | 0.426 | 0.748 | 0.494 | 0.733 | 0.122 | 0.556 | 0.343 | 0.741 |
1040686 | HLA-DPA1*02:02/DPB1*05:01 | 1563 | 259 | binary | - | - | - | - | - | - | - | - | 0.046 | 0.536 | 0.082 | 0.564 | 0.098 | 0.576 | 0.103 | 0.581 | 0.114 | 0.588 | 0.115 | 0.591 | 0.103 | 0.580 | 0.108 | 0.585 | 0.125 | 0.597 | 0.183 | 0.643 | - | - | - | - |
1040686 | HLA-DQA1*03:01/DQB1*03:02 | 1258 | 189 | binary | 0.106 | 0.590 | 0.264 | 0.715 | 0.262 | 0.712 | 0.252 | 0.703 | 0.250 | 0.702 | 0.219 | 0.677 | 0.221 | 0.678 | 0.135 | 0.609 | 0.205 | 0.666 | 0.144 | 0.617 | 0.229 | 0.685 | 0.174 | 0.642 | 0.240 | 0.694 | 0.195 | 0.659 | 0.270 | 0.718 | - | - |
1040686 | HLA-DRB1*04:01 | 425 | 65 | binary | - | - | -0.068 | 0.450 | -0.086 | 0.431 | -0.072 | 0.442 | -0.064 | 0.449 | -0.073 | 0.441 | -0.064 | 0.449 | 0.022 | 0.523 | -0.060 | 0.452 | 0.061 | 0.551 | -0.056 | 0.455 | 0.073 | 0.560 | -0.037 | 0.470 | 0.033 | 0.528 | -0.069 | 0.445 | -0.136 | 0.401 |
1040686 | HLA-DRB1*04:04 | 9788 | 1471 | binary | - | - | 0.254 | 0.705 | 0.160 | 0.629 | 0.243 | 0.696 | 0.200 | 0.661 | 0.260 | 0.710 | 0.278 | 0.724 | 0.287 | 0.732 | 0.287 | 0.732 | 0.313 | 0.754 | 0.291 | 0.735 | 0.322 | 0.760 | 0.301 | 0.743 | 0.320 | 0.758 | 0.212 | 0.671 | 0.249 | 0.702 |
1040686 | HLA-DRB1*07:01 | 9797 | 1485 | binary | 0.207 | 0.667 | 0.319 | 0.756 | 0.299 | 0.741 | 0.311 | 0.750 | 0.276 | 0.723 | 0.308 | 0.748 | 0.326 | 0.763 | 0.326 | 0.762 | 0.327 | 0.764 | 0.329 | 0.765 | 0.327 | 0.764 | 0.335 | 0.770 | 0.334 | 0.769 | 0.323 | 0.760 | 0.314 | 0.753 | 0.235 | 0.689 |
1040686 | HLA-DRB1*07:01 | 33 | 11 | ic50 | 0.317 | 0.678 | 0.627 | 0.835 | 0.707 | 0.880 | 0.662 | 0.872 | 0.693 | 0.868 | 0.688 | 0.884 | 0.795 | 0.955 | 0.706 | 0.868 | 0.811 | 0.963 | 0.688 | 0.876 | 0.770 | 0.934 | 0.737 | 0.888 | 0.758 | 0.942 | 0.715 | 0.884 | 0.642 | 0.822 | 0.571 | 0.746 |
1040686 | HLA-DRB1*08:03 | 1949 | 320 | binary | - | - | - | - | - | - | - | - | 0.057 | 0.544 | 0.026 | 0.520 | 0.009 | 0.507 | 0.052 | 0.541 | 0.010 | 0.508 | 0.067 | 0.553 | 0.038 | 0.530 | 0.092 | 0.572 | 0.055 | 0.543 | 0.082 | 0.565 | - | - | - | - |
1040686 | HLA-DRB1*11:01 | 633 | 96 | binary | - | - | 0.078 | 0.566 | 0.045 | 0.536 | 0.098 | 0.579 | 0.011 | 0.509 | 0.087 | 0.570 | 0.111 | 0.589 | 0.154 | 0.626 | 0.109 | 0.588 | 0.156 | 0.627 | 0.122 | 0.598 | 0.161 | 0.632 | 0.138 | 0.611 | 0.154 | 0.625 | 0.047 | 0.539 | 0.057 | 0.555 |
1040686 | HLA-DRB1*14:05 | 1949 | 333 | binary | - | - | - | - | - | - | - | - | 0.179 | 0.637 | 0.255 | 0.696 | 0.217 | 0.666 | 0.210 | 0.662 | 0.242 | 0.686 | 0.250 | 0.692 | 0.266 | 0.704 | 0.260 | 0.700 | 0.271 | 0.708 | 0.248 | 0.690 | - | - | - | - |
1040686 | HLA-DRB1*15:01 | 9797 | 1485 | binary | - | - | 0.198 | 0.659 | 0.115 | 0.593 | 0.201 | 0.662 | 0.137 | 0.611 | 0.180 | 0.645 | 0.214 | 0.672 | 0.246 | 0.698 | 0.221 | 0.679 | 0.269 | 0.716 | 0.220 | 0.677 | 0.273 | 0.720 | 0.220 | 0.677 | 0.276 | 0.722 | 0.168 | 0.635 | 0.200 | 0.662 |
1040686 | HLA-DRB1*15:01 | 33 | 4 | ic50 | - | - | 0.748 | 0.940 | 0.469 | 0.888 | 0.731 | 0.905 | 0.658 | 0.931 | 0.679 | 0.931 | 0.702 | 0.922 | 0.571 | 0.750 | 0.711 | 0.922 | 0.530 | 0.716 | 0.667 | 0.922 | 0.512 | 0.698 | 0.710 | 0.922 | 0.507 | 0.733 | 0.506 | 0.931 | 0.736 | 0.892 |
1040281 | HLA-DPA1*01:03/DPB1*04:01 | 12 | 2 | binary | - | - | - | - | - | - | 0.648 | 1.000 | 0.648 | 1.000 | 0.648 | 1.000 | 0.389 | 0.800 | 0.130 | 0.600 | 0.389 | 0.800 | 0.389 | 0.800 | 0.389 | 0.800 | 0.260 | 0.700 | 0.389 | 0.800 | 0.454 | 0.850 | - | - | - | - |
1040281 | HLA-DRB1*01:01 | 12 | 8 | binary | 0.180 | 0.609 | 0.103 | 0.594 | -0.154 | 0.406 | -0.051 | 0.469 | -0.154 | 0.406 | -0.128 | 0.422 | -0.102 | 0.438 | 0.051 | 0.531 | -0.102 | 0.438 | 0.051 | 0.531 | -0.154 | 0.406 | 0.051 | 0.531 | -0.307 | 0.312 | 0.051 | 0.531 | 0.000 | 0.500 | 0.103 | 0.562 |
1040281 | HLA-DRB1*03:01 | 12 | 2 | binary | - | - | 0.033 | 0.750 | 0.194 | 0.650 | 0.000 | 0.500 | 0.518 | 0.900 | 0.453 | 0.850 | 0.389 | 0.800 | 0.453 | 0.850 | 0.389 | 0.800 | 0.518 | 0.900 | 0.518 | 0.900 | 0.422 | 0.900 | 0.324 | 0.750 | 0.422 | 0.900 | 0.194 | 0.650 | -0.033 | 0.525 |
1040281 | HLA-DRB1*04:01 | 12 | 5 | binary | - | - | 0.860 | 1.000 | 0.759 | 0.943 | 0.661 | 0.886 | 0.759 | 0.943 | 0.857 | 1.000 | 0.808 | 0.971 | 0.857 | 1.000 | 0.857 | 1.000 | 0.857 | 1.000 | 0.857 | 1.000 | 0.857 | 1.000 | 0.857 | 1.000 | 0.857 | 1.000 | 0.857 | 1.000 | 0.861 | 1.000 |
1040281 | HLA-DRB1*07:01 | 12 | 8 | binary | 0.026 | 0.516 | 0.359 | 0.719 | 0.358 | 0.719 | 0.358 | 0.719 | 0.615 | 0.875 | 0.512 | 0.812 | 0.512 | 0.812 | 0.512 | 0.812 | 0.461 | 0.781 | 0.563 | 0.844 | 0.461 | 0.781 | 0.512 | 0.812 | 0.563 | 0.844 | 0.563 | 0.844 | 0.307 | 0.688 | 0.263 | 0.750 |
1040281 | HLA-DRB1*08:01 | 12 | 7 | binary | - | - | 0.246 | 0.643 | - | - | 0.220 | 0.629 | 0.808 | 0.971 | 0.465 | 0.771 | 0.416 | 0.743 | 0.563 | 0.829 | 0.367 | 0.714 | 0.416 | 0.743 | 0.465 | 0.771 | 0.269 | 0.657 | 0.514 | 0.800 | 0.220 | 0.629 | - | - | 0.246 | 0.643 |
1040281 | HLA-DRB1*15:01 | 12 | 3 | binary | - | - | - | - | 0.418 | 0.778 | 0.753 | 1.000 | 0.418 | 0.778 | 0.530 | 0.852 | 0.697 | 0.963 | 0.753 | 1.000 | 0.697 | 0.963 | 0.697 | 0.963 | 0.697 | 0.963 | 0.698 | 0.963 | 0.753 | 1.000 | 0.641 | 0.926 | 0.698 | 0.963 | 0.283 | 0.722 |
1040281 | HLA-DRB3*01:01 | 12 | 3 | binary | 0.028 | 0.519 | 0.755 | 1.000 | 0.754 | 1.000 | 0.753 | 1.000 | 0.753 | 1.000 | 0.753 | 1.000 | 0.753 | 1.000 | 0.754 | 1.000 | 0.753 | 1.000 | 0.753 | 1.000 | 0.753 | 1.000 | 0.754 | 1.000 | 0.753 | 1.000 | 0.754 | 1.000 | 0.753 | 1.000 | - | - |
1040281 | HLA-DRB3*02:02 | 12 | 9 | binary | - | - | - | - | - | - | 0.362 | 0.741 | 0.697 | 0.963 | 0.418 | 0.778 | 0.585 | 0.889 | 0.586 | 0.889 | 0.586 | 0.889 | 0.641 | 0.926 | 0.585 | 0.889 | 0.697 | 0.963 | 0.585 | 0.889 | 0.585 | 0.889 | - | - | - | - |
1040281 | HLA-DRB4*01:01 | 12 | 3 | binary | -0.084 | 0.444 | -0.084 | 0.444 | 0.139 | 0.593 | 0.362 | 0.741 | 0.139 | 0.593 | 0.195 | 0.630 | 0.195 | 0.630 | -0.251 | 0.333 | 0.139 | 0.593 | -0.474 | 0.185 | 0.028 | 0.519 | -0.418 | 0.222 | -0.028 | 0.481 | -0.307 | 0.296 | -0.084 | 0.444 | - | - |
1040281 | HLA-DRB5*01:01 | 12 | 8 | binary | - | - | 0.103 | 0.594 | -0.051 | 0.469 | -0.154 | 0.406 | 0.051 | 0.531 | -0.051 | 0.469 | 0.000 | 0.500 | 0.205 | 0.625 | -0.051 | 0.469 | 0.154 | 0.594 | -0.102 | 0.438 | 0.205 | 0.625 | 0.000 | 0.500 | 0.154 | 0.594 | 0.410 | 0.750 | 0.207 | 0.656 |
1041296 | HLA-DRB1*01:01 | 14 | 4 | ic50 | 0.511 | 0.700 | 0.880 | 0.962 | 0.748 | 0.950 | 0.869 | 1.000 | 0.766 | 0.875 | 0.829 | 0.925 | 0.807 | 0.900 | 0.689 | 0.800 | 0.785 | 0.875 | 0.675 | 0.775 | 0.812 | 0.875 | 0.774 | 0.825 | 0.752 | 0.825 | 0.744 | 0.850 | 0.812 | 0.875 | 0.441 | 0.825 |
1041296 | HLA-DRB1*04:01 | 14 | 4 | ic50 | - | - | 0.064 | 0.500 | 0.231 | 0.625 | -0.037 | 0.500 | 0.240 | 0.675 | 0.191 | 0.675 | 0.064 | 0.550 | -0.359 | 0.363 | 0.095 | 0.550 | -0.143 | 0.400 | 0.033 | 0.575 | -0.095 | 0.450 | 0.055 | 0.575 | -0.262 | 0.325 | 0.046 | 0.500 | 0.196 | 0.550 |
1041296 | HLA-DRB1*04:05 | 14 | 2 | ic50 | - | - | 0.508 | 0.583 | 0.741 | 0.875 | 0.684 | 0.833 | 0.248 | 0.542 | 0.248 | 0.583 | 0.218 | 0.500 | 0.125 | 0.583 | 0.262 | 0.542 | 0.297 | 0.708 | 0.209 | 0.583 | 0.266 | 0.812 | 0.402 | 0.542 | 0.341 | 0.708 | 0.490 | 0.583 | 0.442 | 0.667 |
1041296 | HLA-DRB1*07:01 | 14 | 6 | ic50 | 0.423 | 0.625 | 0.735 | 0.833 | 0.829 | 0.958 | 0.748 | 0.875 | 0.761 | 0.875 | 0.834 | 0.938 | 0.858 | 0.958 | 0.783 | 0.812 | 0.827 | 0.917 | 0.715 | 0.792 | 0.860 | 0.938 | 0.803 | 0.833 | 0.867 | 0.938 | 0.680 | 0.771 | 0.849 | 0.917 | 0.660 | 0.833 |
1041296 | HLA-DRB1*08:02 | 14 | 4 | ic50 | - | - | 0.644 | 0.900 | 0.341 | 0.750 | 0.493 | 0.800 | 0.728 | 0.950 | 0.686 | 0.900 | 0.708 | 0.950 | 0.598 | 0.900 | 0.746 | 0.975 | 0.735 | 0.925 | 0.711 | 0.950 | 0.640 | 0.875 | 0.741 | 0.975 | 0.744 | 0.875 | 0.381 | 0.700 | 0.572 | 0.800 |
1041296 | HLA-DRB1*09:01 | 14 | 8 | ic50 | -0.118 | 0.500 | 0.562 | 0.875 | 0.453 | 0.833 | 0.656 | 0.958 | 0.592 | 0.875 | 0.614 | 0.896 | 0.737 | 0.958 | 0.596 | 0.938 | 0.748 | 0.979 | 0.704 | 0.979 | 0.724 | 0.958 | 0.678 | 0.958 | 0.645 | 0.938 | 0.642 | 0.958 | 0.695 | 0.875 | - | - |
1041296 | HLA-DRB1*11:01 | 14 | 8 | ic50 | - | - | 0.764 | 0.875 | 0.793 | 0.854 | 0.837 | 0.875 | 0.758 | 0.875 | 0.807 | 0.896 | 0.807 | 0.896 | 0.604 | 0.688 | 0.776 | 0.875 | 0.670 | 0.729 | 0.793 | 0.896 | 0.688 | 0.729 | 0.833 | 0.896 | 0.684 | 0.729 | 0.722 | 0.792 | 0.726 | 0.896 |
1041296 | HLA-DRB1*12:01 | 14 | 4 | ic50 | - | - | 0.675 | 0.912 | - | - | 0.666 | 0.850 | 0.600 | 0.850 | 0.653 | 0.850 | 0.727 | 0.875 | 0.481 | 0.750 | 0.670 | 0.875 | 0.385 | 0.775 | 0.723 | 0.875 | 0.284 | 0.688 | 0.697 | 0.875 | 0.473 | 0.825 | 0.600 | 0.800 | - | - |
1041296 | HLA-DRB1*15:01 | 14 | 6 | ic50 | - | - | 0.868 | 0.958 | 0.662 | 0.979 | 0.780 | 0.938 | 0.785 | 1.000 | 0.815 | 0.979 | 0.873 | 1.000 | 0.490 | 0.667 | 0.864 | 1.000 | 0.512 | 0.667 | 0.776 | 0.938 | 0.481 | 0.667 | 0.785 | 0.958 | 0.495 | 0.688 | 0.626 | 0.833 | 0.861 | 0.948 |