MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
Comblib matrices | 16 | 20 | 12 |
Consensus IEDB method | 69 | 67 | 72 |
NN-align | 59 | 59 | 58 |
NN-align 2.3 | 66 | 62 | 71 |
NetMHCIIpan-3.1 | 42 | 46 | 38 |
NetMHCIIpan-3.2 | 51 | 50 | 52 |
NetMHCIIpan-4.0 BA | 66 | 67 | 65 |
NetMHCIIpan-4.0 EL | 31 | 24 | 39 |
NetMHCIIpan-4.1 BA | 66 | 71 | 60 |
NetMHCIIpan-4.1 EL | 32 | 24 | 41 |
NetMHCIIpan-4.2 BA | 63 | 70 | 56 |
NetMHCIIpan-4.2 EL | 37 | 29 | 45 |
NetMHCIIpan-4.3 BA | 64 | 68 | 60 |
NetMHCIIpan-4.3 EL | 36 | 29 | 43 |
SMM-align | 52 | 53 | 51 |
Tepitope (Sturniolo) | 42 | 44 | 40 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
1039423 | HLA-DRB1*01:01 | 43 | 28 | ic50 | 0.232 | 0.595 | 0.656 | 0.781 | 0.558 | 0.773 | 0.711 | 0.821 | 0.648 | 0.786 | 0.622 | 0.798 | 0.622 | 0.781 | 0.361 | 0.617 | 0.637 | 0.788 | 0.355 | 0.624 | 0.610 | 0.774 | 0.368 | 0.621 | 0.664 | 0.810 | 0.356 | 0.630 | 0.570 | 0.695 | 0.425 | 0.668 |
1039423 | HLA-DRB1*03:03 | 43 | 5 | ic50 | - | - | - | - | - | - | - | - | 0.327 | 0.679 | 0.393 | 0.768 | 0.408 | 0.732 | 0.104 | 0.663 | 0.275 | 0.668 | 0.109 | 0.647 | 0.291 | 0.647 | 0.095 | 0.637 | 0.358 | 0.689 | 0.096 | 0.637 | - | - | - | - |
1039423 | HLA-DRB1*04:01 | 43 | 4 | ic50 | - | - | 0.457 | 0.885 | 0.438 | 0.827 | 0.365 | 0.917 | 0.391 | 0.801 | 0.393 | 0.923 | 0.373 | 0.865 | 0.138 | 0.840 | 0.398 | 0.859 | 0.142 | 0.853 | 0.352 | 0.859 | 0.164 | 0.840 | 0.376 | 0.878 | 0.194 | 0.859 | 0.480 | 0.846 | 0.436 | 0.792 |
1039423 | HLA-DRB1*07:01 | 43 | 9 | ic50 | 0.228 | 0.699 | 0.434 | 0.797 | 0.487 | 0.791 | 0.441 | 0.781 | 0.321 | 0.722 | 0.431 | 0.781 | 0.492 | 0.807 | 0.208 | 0.755 | 0.496 | 0.804 | 0.217 | 0.771 | 0.452 | 0.778 | 0.214 | 0.784 | 0.419 | 0.771 | 0.205 | 0.761 | 0.344 | 0.709 | 0.562 | 0.828 |
1039423 | HLA-DRB1*08:01 | 43 | 2 | ic50 | - | - | 0.400 | 0.817 | - | - | 0.449 | 0.744 | 0.343 | 0.500 | 0.338 | 0.720 | 0.385 | 0.732 | 0.390 | 0.744 | 0.419 | 0.732 | 0.412 | 0.756 | 0.430 | 0.683 | 0.438 | 0.744 | 0.389 | 0.695 | 0.432 | 0.707 | - | - | 0.405 | 0.817 |
1039423 | HLA-DRB1*11:01 | 43 | 9 | ic50 | - | - | 0.477 | 0.763 | 0.372 | 0.614 | 0.371 | 0.660 | 0.337 | 0.605 | 0.342 | 0.644 | 0.396 | 0.647 | 0.279 | 0.605 | 0.413 | 0.650 | 0.275 | 0.605 | 0.393 | 0.634 | 0.291 | 0.614 | 0.358 | 0.627 | 0.263 | 0.611 | 0.326 | 0.683 | 0.488 | 0.773 |
1039423 | HLA-DRB1*15:01 | 43 | 14 | ic50 | - | - | 0.678 | 0.840 | 0.534 | 0.756 | 0.640 | 0.803 | 0.422 | 0.690 | 0.531 | 0.736 | 0.683 | 0.842 | 0.510 | 0.879 | 0.686 | 0.835 | 0.517 | 0.847 | 0.667 | 0.830 | 0.488 | 0.833 | 0.668 | 0.813 | 0.534 | 0.847 | 0.523 | 0.739 | 0.578 | 0.837 |
1039777 | H2-IAb | 28 | 2 | ic50 | - | - | - | - | 0.566 | 0.865 | 0.411 | 0.942 | 0.545 | 0.788 | 0.493 | 0.846 | 0.571 | 1.000 | 0.602 | 1.000 | 0.576 | 1.000 | 0.590 | 1.000 | 0.555 | 1.000 | 0.588 | 1.000 | 0.530 | 1.000 | 0.527 | 1.000 | 0.485 | 0.808 | - | - |
1036897 | HLA-DQA1*01:01/DQB1*05:01 | 28 | 5 | ic50 | 0.409 | 0.848 | 0.710 | 0.935 | 0.806 | 0.904 | 0.780 | 0.939 | 0.732 | 0.896 | 0.695 | 0.922 | 0.731 | 0.930 | 0.557 | 0.800 | 0.733 | 0.922 | 0.612 | 0.857 | 0.731 | 0.939 | 0.548 | 0.791 | 0.785 | 0.957 | 0.458 | 0.765 | 0.658 | 0.922 | - | - |
1036897 | HLA-DQA1*01:02/DQB1*06:02 | 28 | 5 | ic50 | 0.508 | 0.696 | 0.741 | 0.865 | 0.729 | 0.887 | 0.724 | 0.870 | 0.632 | 0.739 | 0.639 | 0.765 | 0.781 | 0.835 | - | - | 0.793 | 0.852 | 0.475 | 0.861 | 0.745 | 0.817 | 0.472 | 0.870 | 0.800 | 0.843 | 0.458 | 0.861 | 0.794 | 0.852 | - | - |
1036897 | HLA-DQA1*05:01/DQB1*02:01 | 28 | 6 | ic50 | 0.134 | 0.413 | 0.590 | 0.712 | 0.553 | 0.697 | 0.597 | 0.712 | 0.424 | 0.561 | 0.509 | 0.644 | 0.448 | 0.667 | 0.492 | 0.765 | 0.503 | 0.674 | 0.498 | 0.705 | 0.482 | 0.682 | 0.502 | 0.705 | 0.527 | 0.689 | 0.499 | 0.750 | 0.612 | 0.697 | - | - |
1036897 | HLA-DRB1*01:01 | 28 | 10 | ic50 | 0.517 | 0.647 | 0.745 | 0.800 | 0.702 | 0.783 | 0.734 | 0.767 | 0.619 | 0.678 | 0.632 | 0.700 | 0.639 | 0.689 | 0.352 | 0.672 | 0.599 | 0.661 | 0.432 | 0.717 | 0.623 | 0.667 | 0.459 | 0.753 | 0.623 | 0.672 | 0.459 | 0.778 | 0.665 | 0.756 | 0.427 | 0.683 |
1036897 | HLA-DRB1*04:01 | 28 | 13 | ic50 | - | - | 0.575 | 0.762 | 0.372 | 0.785 | 0.386 | 0.703 | 0.530 | 0.785 | 0.458 | 0.718 | 0.605 | 0.785 | 0.590 | 0.785 | 0.587 | 0.779 | 0.606 | 0.795 | 0.567 | 0.759 | 0.620 | 0.826 | 0.555 | 0.764 | 0.650 | 0.821 | 0.630 | 0.826 | 0.567 | 0.710 |
1036897 | HLA-DRB1*04:05 | 28 | 9 | ic50 | - | - | 0.622 | 0.781 | 0.363 | 0.673 | 0.609 | 0.772 | 0.611 | 0.719 | 0.547 | 0.708 | 0.661 | 0.795 | 0.538 | 0.819 | 0.653 | 0.778 | 0.509 | 0.836 | 0.668 | 0.795 | 0.544 | 0.865 | 0.761 | 0.865 | 0.554 | 0.857 | 0.552 | 0.842 | 0.630 | 0.725 |
1036897 | HLA-DRB1*07:01 | 28 | 9 | ic50 | 0.649 | 0.734 | 0.890 | 0.936 | 0.823 | 0.860 | 0.858 | 0.906 | 0.762 | 0.795 | 0.842 | 0.842 | 0.879 | 0.871 | 0.529 | 0.836 | 0.887 | 0.877 | 0.530 | 0.836 | 0.906 | 0.901 | 0.531 | 0.842 | 0.880 | 0.883 | 0.537 | 0.860 | 0.815 | 0.915 | 0.529 | 0.719 |
1036897 | HLA-DRB1*08:02 | 28 | 6 | ic50 | - | - | 0.233 | 0.659 | 0.051 | 0.553 | 0.189 | 0.674 | 0.551 | 0.826 | 0.531 | 0.856 | 0.629 | 0.848 | 0.283 | 0.583 | 0.694 | 0.894 | 0.297 | 0.617 | 0.663 | 0.886 | 0.398 | 0.621 | 0.488 | 0.788 | 0.383 | 0.659 | 0.177 | 0.545 | 0.396 | 0.561 |
1036897 | HLA-DRB1*09:01 | 28 | 20 | ic50 | 0.546 | 0.684 | 0.731 | 0.831 | 0.716 | 0.863 | 0.753 | 0.863 | 0.643 | 0.781 | 0.726 | 0.831 | 0.735 | 0.819 | 0.413 | 0.675 | 0.799 | 0.850 | 0.600 | 0.800 | 0.812 | 0.856 | 0.609 | 0.794 | 0.782 | 0.844 | 0.604 | 0.781 | 0.597 | 0.819 | - | - |
1036897 | HLA-DRB1*11:01 | 28 | 2 | ic50 | - | - | 0.645 | 0.933 | 0.730 | 0.942 | 0.622 | 0.885 | 0.662 | 0.808 | 0.706 | 0.885 | 0.741 | 0.904 | 0.463 | 0.558 | 0.746 | 0.923 | 0.453 | 0.654 | 0.795 | 0.885 | 0.481 | 0.538 | 0.810 | 0.923 | 0.619 | 0.712 | 0.754 | 0.962 | 0.637 | 0.885 |
1036897 | HLA-DRB1*12:01 | 28 | 4 | ic50 | - | - | 0.681 | 0.885 | - | - | 0.694 | 0.896 | 0.534 | 0.844 | 0.631 | 0.865 | 0.683 | 0.948 | 0.706 | 0.979 | 0.706 | 0.948 | 0.695 | 0.969 | 0.745 | 0.938 | 0.719 | 0.969 | 0.727 | 0.938 | 0.772 | 0.938 | 0.421 | 0.667 | - | - |
1036897 | HLA-DRB1*13:02 | 28 | 5 | ic50 | - | - | 0.529 | 0.874 | 0.551 | 0.870 | 0.595 | 0.896 | 0.457 | 0.904 | 0.454 | 0.809 | 0.344 | 0.757 | 0.353 | 0.643 | 0.359 | 0.757 | 0.336 | 0.591 | 0.475 | 0.809 | 0.337 | 0.635 | 0.480 | 0.817 | 0.295 | 0.600 | 0.526 | 0.739 | -0.051 | 0.739 |
1036897 | HLA-DRB1*15:01 | 28 | 22 | ic50 | - | - | 0.755 | 0.837 | 0.807 | 0.841 | 0.766 | 0.871 | 0.683 | 0.811 | 0.804 | 0.871 | 0.812 | 0.886 | 0.485 | 0.697 | 0.765 | 0.871 | 0.467 | 0.697 | 0.811 | 0.871 | 0.481 | 0.727 | 0.779 | 0.856 | 0.468 | 0.758 | 0.787 | 0.818 | 0.717 | 0.769 |
1036897 | HLA-DRB3*01:01 | 28 | 4 | ic50 | 0.428 | 0.896 | 0.732 | 0.979 | 0.539 | 0.854 | 0.746 | 0.979 | 0.659 | 0.948 | 0.697 | 0.958 | 0.599 | 0.802 | 0.390 | 0.802 | 0.592 | 0.792 | 0.426 | 0.792 | 0.637 | 0.833 | 0.413 | 0.833 | 0.642 | 0.854 | 0.532 | 0.823 | 0.614 | 0.865 | - | - |
1036897 | HLA-DRB4*01:01 | 28 | 14 | ic50 | 0.397 | 0.765 | 0.651 | 0.872 | 0.647 | 0.852 | 0.662 | 0.888 | 0.616 | 0.867 | 0.581 | 0.837 | 0.542 | 0.816 | 0.470 | 0.798 | 0.544 | 0.821 | 0.404 | 0.760 | 0.479 | 0.776 | 0.517 | 0.804 | 0.549 | 0.781 | 0.465 | 0.763 | 0.689 | 0.949 | - | - |
1036897 | HLA-DRB5*01:01 | 28 | 8 | ic50 | - | - | 0.681 | 0.850 | 0.659 | 0.881 | 0.723 | 0.825 | 0.699 | 0.888 | 0.704 | 0.862 | 0.661 | 0.825 | 0.451 | 0.722 | 0.660 | 0.819 | 0.396 | 0.663 | 0.705 | 0.850 | 0.443 | 0.713 | 0.634 | 0.819 | 0.423 | 0.694 | 0.515 | 0.787 | 0.489 | 0.728 |
1035763 | HLA-DRB1*01:01 | 29 | 21 | ic50 | 0.475 | 0.685 | 0.406 | 0.717 | 0.493 | 0.833 | 0.333 | 0.762 | 0.400 | 0.744 | 0.163 | 0.589 | 0.523 | 0.726 | 0.366 | 0.720 | 0.454 | 0.708 | 0.286 | 0.690 | 0.544 | 0.786 | 0.276 | 0.696 | 0.433 | 0.702 | 0.359 | 0.732 | 0.424 | 0.732 | 0.212 | 0.661 |
1040391 | H2-IAb | 52 | 18 | ic50 | - | - | 0.443 | 0.675 | 0.479 | 0.652 | 0.442 | 0.693 | 0.445 | 0.663 | 0.455 | 0.678 | 0.555 | 0.770 | 0.348 | 0.612 | 0.559 | 0.763 | 0.368 | 0.641 | 0.519 | 0.732 | 0.331 | 0.601 | 0.540 | 0.740 | 0.352 | 0.595 | 0.418 | 0.637 | - | - |