MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
Comblib matrices | 16 | 13 | 19 |
Consensus IEDB method | 62 | 61 | 63 |
NN-align | 56 | 58 | 53 |
NN-align 2.3 | 67 | 67 | 68 |
NetMHCIIpan-3.1 | 50 | 51 | 48 |
NetMHCIIpan-3.2 | 70 | 69 | 71 |
NetMHCIIpan-4.0 BA | 62 | 57 | 66 |
NetMHCIIpan-4.0 EL | 35 | 27 | 43 |
NetMHCIIpan-4.1 BA | 65 | 64 | 66 |
NetMHCIIpan-4.1 EL | 37 | 32 | 42 |
NetMHCIIpan-4.2 BA | 64 | 62 | 66 |
NetMHCIIpan-4.2 EL | 40 | 36 | 43 |
NetMHCIIpan-4.3 BA | 73 | 67 | 78 |
NetMHCIIpan-4.3 EL | 32 | 29 | 35 |
SMM-align | 52 | 51 | 53 |
Tepitope (Sturniolo) | 41 | 37 | 44 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
1038478 | HLA-DRB1*15:01 | 19 | 16 | binary | - | - | 0.132 | 0.604 | 0.369 | 0.792 | - | - | 0.553 | 0.938 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.237 | 0.688 | -0.106 | 0.417 |
1038237 | HLA-DRB1*01:01 | 18 | 3 | ic50 | -0.011 | 0.633 | 0.382 | 0.811 | 0.350 | 0.756 | - | - | 0.401 | 0.800 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.463 | 0.867 | 0.588 | 0.867 |
1038237 | HLA-DRB1*04:01 | 18 | 8 | ic50 | - | - | 0.366 | 0.762 | 0.245 | 0.713 | - | - | 0.197 | 0.625 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.358 | 0.725 | 0.293 | 0.738 |
1038237 | HLA-DRB1*04:05 | 18 | 6 | ic50 | - | - | 0.595 | 0.819 | 0.587 | 0.778 | - | - | 0.509 | 0.764 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.643 | 0.861 | 0.311 | 0.736 |
1038237 | HLA-DRB1*07:01 | 18 | 6 | ic50 | 0.750 | 0.861 | 0.649 | 0.854 | 0.534 | 0.889 | - | - | 0.655 | 0.889 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.680 | 0.903 | 0.541 | 0.875 |
1038237 | HLA-DRB1*08:02 | 18 | 2 | ic50 | - | - | 0.300 | 0.922 | 0.238 | 0.875 | - | - | 0.366 | 0.969 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.278 | 0.938 | 0.211 | 0.906 |
1038237 | HLA-DRB1*09:01 | 18 | 4 | ic50 | -0.367 | 0.384 | 0.540 | 0.946 | 0.581 | 1.000 | - | - | 0.534 | 0.964 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.461 | 0.964 | - | - |
1038237 | HLA-DRB1*15:01 | 18 | 8 | ic50 | - | - | 0.700 | 0.887 | 0.461 | 0.812 | - | - | 0.470 | 0.825 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.738 | 0.900 | 0.551 | 0.800 |
1038237 | HLA-DRB3*01:01 | 18 | 3 | ic50 | -0.024 | 0.578 | 0.789 | 0.989 | 0.755 | 0.956 | - | - | 0.834 | 0.889 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.888 | 1.000 | - | - |
1038237 | HLA-DRB4*01:01 | 18 | 4 | ic50 | 0.246 | 0.804 | 0.465 | 0.929 | 0.574 | 0.964 | - | - | 0.555 | 0.857 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.539 | 0.875 | - | - |
1038973 | HLA-DQA1*01:02/DQB1*06:02 | 30 | 25 | binary | 0.347 | 0.768 | 0.444 | 0.844 | 0.532 | 0.912 | - | - | 0.481 | 0.872 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.439 | 0.840 | - | - |
1038973 | HLA-DRB1*04:01 | 180 | 90 | binary | - | - | 0.304 | 0.677 | 0.347 | 0.701 | - | - | 0.275 | 0.659 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.235 | 0.636 | 0.238 | 0.639 |
1039545 | HLA-DPA1*01:03/DPB1*04:01 | 14 | 2 | ic50 | - | - | - | - | - | - | 0.638 | 0.708 | 0.238 | 0.542 | 0.460 | 0.625 | 0.449 | 0.625 | 0.244 | 0.875 | 0.511 | 0.667 | 0.629 | 0.958 | 0.520 | 0.667 | 0.503 | 0.979 | 0.567 | 0.708 | 0.189 | 0.708 | - | - | - | - |
1039545 | HLA-DQA1*01:02/DQB1*06:02 | 14 | 2 | ic50 | 0.336 | 0.875 | 0.801 | 0.917 | 0.647 | 0.625 | 0.775 | 0.875 | 0.779 | 0.792 | 0.793 | 0.833 | 0.762 | 0.917 | 0.567 | 0.958 | 0.669 | 0.917 | 0.625 | 0.917 | 0.687 | 0.958 | 0.667 | 0.958 | 0.748 | 1.000 | 0.621 | 0.958 | 0.766 | 0.917 | - | - |
1039545 | HLA-DQA1*03:01/DQB1*03:02 | 14 | 2 | ic50 | 0.101 | 0.688 | 0.852 | 1.000 | 0.811 | 0.958 | 0.879 | 1.000 | 0.753 | 0.958 | 0.784 | 1.000 | 0.753 | 1.000 | 0.286 | 1.000 | 0.708 | 1.000 | 0.473 | 1.000 | 0.744 | 1.000 | 0.443 | 1.000 | 0.627 | 1.000 | 0.569 | 0.917 | 0.826 | 1.000 | - | - |
1039545 | HLA-DQA1*05:01/DQB1*02:01 | 14 | 2 | ic50 | 0.655 | 0.938 | 0.757 | 1.000 | 0.897 | 0.917 | 0.816 | 1.000 | 0.753 | 0.875 | 0.838 | 0.958 | 0.843 | 0.917 | 0.470 | 0.875 | 0.838 | 0.917 | 0.452 | 0.875 | 0.928 | 0.958 | 0.510 | 0.875 | 0.888 | 0.958 | 0.524 | 0.875 | 0.780 | 0.917 | - | - |
1039545 | HLA-DRB1*01:01 | 14 | 12 | ic50 | 0.331 | 0.958 | 0.645 | 0.958 | 0.662 | 0.958 | 0.612 | 0.917 | 0.730 | 0.958 | 0.785 | 0.958 | 0.785 | 0.958 | 0.801 | 0.833 | 0.856 | 0.958 | 0.817 | 0.833 | 0.741 | 0.958 | 0.836 | 0.875 | 0.693 | 1.000 | 0.781 | 0.708 | 0.202 | 0.667 | 0.496 | 1.000 |
1039545 | HLA-DRB1*04:01 | 14 | 4 | ic50 | - | - | 0.392 | 0.825 | 0.393 | 0.825 | 0.516 | 0.850 | 0.719 | 0.900 | 0.723 | 0.925 | 0.635 | 0.925 | 0.692 | 0.875 | 0.648 | 0.925 | 0.684 | 0.875 | 0.657 | 0.975 | 0.749 | 0.950 | 0.710 | 0.975 | 0.702 | 0.950 | 0.231 | 0.750 | 0.344 | 0.713 |
1039545 | HLA-DRB1*04:05 | 14 | 3 | ic50 | - | - | 0.812 | 0.909 | 0.811 | 0.848 | 0.714 | 1.000 | 0.793 | 1.000 | 0.829 | 0.909 | 0.793 | 0.939 | 0.481 | 0.788 | 0.807 | 0.970 | 0.449 | 0.818 | 0.644 | 0.909 | 0.477 | 0.788 | 0.714 | 0.970 | 0.516 | 0.818 | 0.741 | 0.788 | 0.782 | 0.909 |
1039545 | HLA-DRB1*07:01 | 14 | 8 | ic50 | 0.697 | 1.000 | 0.791 | 1.000 | 0.780 | 0.979 | 0.802 | 1.000 | 0.846 | 1.000 | 0.874 | 0.958 | 0.643 | 0.812 | 0.811 | 0.896 | 0.665 | 0.854 | 0.764 | 0.854 | 0.795 | 0.938 | 0.716 | 0.812 | 0.857 | 1.000 | 0.736 | 0.812 | 0.692 | 0.917 | 0.667 | 0.885 |
1039545 | HLA-DRB1*08:02 | 14 | 8 | ic50 | - | - | 0.358 | 0.583 | 0.508 | 0.729 | 0.301 | 0.667 | 0.868 | 0.958 | 0.613 | 0.896 | 0.543 | 0.812 | 0.327 | 0.688 | 0.688 | 0.875 | 0.323 | 0.688 | 0.499 | 0.750 | 0.314 | 0.667 | 0.552 | 0.771 | 0.314 | 0.646 | 0.367 | 0.688 | 0.417 | 0.542 |
1039545 | HLA-DRB1*09:01 | 14 | 7 | ic50 | 0.112 | 0.357 | 0.682 | 0.786 | 0.459 | 0.612 | 0.745 | 0.735 | 0.679 | 0.735 | 0.833 | 0.878 | 0.829 | 0.857 | 0.842 | 0.959 | 0.807 | 0.857 | 0.908 | 0.959 | 0.873 | 0.878 | 0.873 | 0.959 | 0.877 | 0.878 | 0.886 | 0.980 | 0.257 | 0.592 | - | - |
1039545 | HLA-DRB1*11:01 | 14 | 11 | ic50 | - | - | 0.577 | 0.864 | 0.757 | 1.000 | 0.739 | 0.939 | 0.717 | 0.970 | 0.774 | 0.970 | 0.719 | 0.939 | 0.295 | 0.697 | 0.759 | 0.909 | 0.235 | 0.636 | 0.759 | 0.939 | 0.213 | 0.636 | 0.750 | 0.970 | 0.185 | 0.636 | 0.691 | 1.000 | 0.344 | 0.758 |
1039545 | HLA-DRB1*12:01 | 14 | 3 | ic50 | - | - | 0.785 | 0.970 | - | - | 0.854 | 1.000 | 0.594 | 0.788 | 0.700 | 0.939 | 0.664 | 0.970 | 0.245 | 0.848 | 0.629 | 0.970 | 0.236 | 0.788 | 0.722 | 0.970 | 0.320 | 0.879 | 0.753 | 0.970 | 0.329 | 0.848 | 0.664 | 0.909 | - | - |
1039545 | HLA-DRB1*13:02 | 14 | 3 | ic50 | - | - | 0.714 | 0.879 | 0.757 | 0.939 | 0.791 | 1.000 | 0.778 | 0.939 | 0.746 | 1.000 | 0.746 | 0.970 | 0.323 | 0.667 | 0.622 | 0.970 | 0.064 | 0.515 | 0.622 | 0.970 | 0.037 | 0.485 | 0.748 | 1.000 | -0.037 | 0.455 | 0.693 | 0.879 | 0.032 | 0.500 |
1039545 | HLA-DRB1*15:01 | 14 | 6 | ic50 | - | - | 0.653 | 0.938 | 0.609 | 0.833 | 0.710 | 0.771 | 0.433 | 0.833 | 0.684 | 0.875 | 0.569 | 0.750 | 0.319 | 0.542 | 0.613 | 0.771 | 0.358 | 0.542 | 0.582 | 0.771 | 0.393 | 0.583 | 0.644 | 0.771 | 0.464 | 0.625 | 0.701 | 0.938 | 0.391 | 0.896 |
1039545 | HLA-DRB3*01:01 | 14 | 5 | ic50 | 0.183 | 0.556 | 0.711 | 0.889 | 0.662 | 0.911 | 0.719 | 0.844 | 0.591 | 0.889 | 0.657 | 0.933 | 0.543 | 0.889 | 0.222 | 0.711 | 0.543 | 0.889 | 0.138 | 0.689 | 0.552 | 0.911 | 0.218 | 0.733 | 0.688 | 0.911 | -0.282 | 0.556 | 0.587 | 0.933 | - | - |
1039545 | HLA-DRB3*02:02 | 14 | 3 | ic50 | - | - | - | - | - | - | 0.554 | 0.879 | 0.207 | 0.758 | 0.658 | 1.000 | 0.521 | 1.000 | 0.629 | 0.848 | 0.451 | 0.970 | 0.695 | 0.909 | 0.543 | 0.970 | 0.636 | 0.848 | 0.726 | 0.970 | 0.537 | 0.788 | - | - | - | - |
1039545 | HLA-DRB4*01:01 | 14 | 2 | ic50 | 0.441 | 0.500 | 0.659 | 0.750 | 0.693 | 0.917 | 0.669 | 1.000 | 0.493 | 0.875 | 0.612 | 0.875 | 0.603 | 0.792 | 0.530 | 0.875 | 0.700 | 0.875 | 0.651 | 0.917 | 0.689 | 0.958 | 0.706 | 0.917 | 0.583 | 1.000 | 0.612 | 0.917 | 0.669 | 0.750 | - | - |
1039545 | HLA-DRB5*01:01 | 14 | 9 | ic50 | - | - | 0.713 | 0.933 | 0.767 | 0.956 | 0.741 | 0.978 | 0.732 | 0.978 | 0.771 | 0.978 | 0.798 | 0.978 | 0.727 | 0.889 | 0.820 | 0.978 | 0.714 | 0.822 | 0.807 | 0.978 | 0.736 | 0.844 | 0.758 | 0.978 | 0.741 | 0.822 | 0.666 | 0.889 | 0.710 | 0.878 |
1039423 | HLA-DRB1*01:01 | 43 | 28 | ic50 | 0.232 | 0.595 | 0.656 | 0.781 | 0.558 | 0.773 | 0.711 | 0.821 | 0.648 | 0.786 | 0.622 | 0.798 | 0.622 | 0.781 | 0.361 | 0.617 | 0.637 | 0.788 | 0.355 | 0.624 | 0.610 | 0.774 | 0.368 | 0.621 | 0.664 | 0.810 | 0.356 | 0.630 | 0.570 | 0.695 | 0.425 | 0.668 |
1039423 | HLA-DRB1*03:03 | 43 | 5 | ic50 | - | - | - | - | - | - | - | - | 0.327 | 0.679 | 0.393 | 0.768 | 0.408 | 0.732 | 0.104 | 0.663 | 0.275 | 0.668 | 0.109 | 0.647 | 0.291 | 0.647 | 0.095 | 0.637 | 0.358 | 0.689 | 0.096 | 0.637 | - | - | - | - |
1039423 | HLA-DRB1*04:01 | 43 | 4 | ic50 | - | - | 0.457 | 0.885 | 0.438 | 0.827 | 0.365 | 0.917 | 0.391 | 0.801 | 0.393 | 0.923 | 0.373 | 0.865 | 0.138 | 0.840 | 0.398 | 0.859 | 0.142 | 0.853 | 0.352 | 0.859 | 0.164 | 0.840 | 0.376 | 0.878 | 0.194 | 0.859 | 0.480 | 0.846 | 0.436 | 0.792 |
1039423 | HLA-DRB1*07:01 | 43 | 9 | ic50 | 0.228 | 0.699 | 0.434 | 0.797 | 0.487 | 0.791 | 0.441 | 0.781 | 0.321 | 0.722 | 0.431 | 0.781 | 0.492 | 0.807 | 0.208 | 0.755 | 0.496 | 0.804 | 0.217 | 0.771 | 0.452 | 0.778 | 0.214 | 0.784 | 0.419 | 0.771 | 0.205 | 0.761 | 0.344 | 0.709 | 0.562 | 0.828 |
1039423 | HLA-DRB1*08:01 | 43 | 2 | ic50 | - | - | 0.400 | 0.817 | - | - | 0.449 | 0.744 | 0.343 | 0.500 | 0.338 | 0.720 | 0.385 | 0.732 | 0.390 | 0.744 | 0.419 | 0.732 | 0.412 | 0.756 | 0.430 | 0.683 | 0.438 | 0.744 | 0.389 | 0.695 | 0.432 | 0.707 | - | - | 0.405 | 0.817 |
1039423 | HLA-DRB1*11:01 | 43 | 9 | ic50 | - | - | 0.477 | 0.763 | 0.372 | 0.614 | 0.371 | 0.660 | 0.337 | 0.605 | 0.342 | 0.644 | 0.396 | 0.647 | 0.279 | 0.605 | 0.413 | 0.650 | 0.275 | 0.605 | 0.393 | 0.634 | 0.291 | 0.614 | 0.358 | 0.627 | 0.263 | 0.611 | 0.326 | 0.683 | 0.488 | 0.773 |
1039423 | HLA-DRB1*15:01 | 43 | 14 | ic50 | - | - | 0.678 | 0.840 | 0.534 | 0.756 | 0.640 | 0.803 | 0.422 | 0.690 | 0.531 | 0.736 | 0.683 | 0.842 | 0.510 | 0.879 | 0.686 | 0.835 | 0.517 | 0.847 | 0.667 | 0.830 | 0.488 | 0.833 | 0.668 | 0.813 | 0.534 | 0.847 | 0.523 | 0.739 | 0.578 | 0.837 |