MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
Server | Overall | SRCC | AUC |
---|---|---|---|
Comblib matrices | 11 | 14 | 9 |
Consensus IEDB method | 66 | 68 | 64 |
NN-align | 64 | 64 | 64 |
NN-align 2.3 | - | - | - |
NetMHCIIpan-3.1 | 57 | 58 | 56 |
NetMHCIIpan-3.2 | - | - | - |
NetMHCIIpan-4.0 BA | - | - | - |
NetMHCIIpan-4.0 EL | - | - | - |
NetMHCIIpan-4.1 BA | - | - | - |
NetMHCIIpan-4.1 EL | - | - | - |
NetMHCIIpan-4.2 BA | - | - | - |
NetMHCIIpan-4.2 EL | - | - | - |
NetMHCIIpan-4.3 BA | - | - | - |
NetMHCIIpan-4.3 EL | - | - | - |
SMM-align | 51 | 49 | 54 |
Tepitope (Sturniolo) | 24 | 21 | 27 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
1037619 | HLA-DRB1*13:02 | 29 | 25 | ic50 | - | - | -0.140 | 0.370 | -0.237 | 0.290 | - | - | -0.063 | 0.530 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -0.237 | 0.400 | 0.607 | 0.930 |
1037619 | HLA-DRB1*15:01 | 23 | 19 | ic50 | - | - | 0.591 | 0.855 | 0.761 | 0.882 | - | - | 0.457 | 0.763 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.492 | 0.895 | 0.451 | 0.691 |
1037619 | HLA-DRB3*03:01 | 31 | 26 | ic50 | - | - | - | - | - | - | - | - | 0.501 | 0.700 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
1037798 | HLA-DRB1*01:01 | 49 | 28 | ic50 | 0.628 | 0.841 | 0.720 | 0.854 | 0.740 | 0.855 | - | - | 0.798 | 0.896 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.672 | 0.827 | 0.455 | 0.738 |
1037798 | HLA-DRB1*04:01 | 49 | 7 | ic50 | - | - | 0.602 | 0.903 | 0.620 | 0.837 | - | - | 0.745 | 0.918 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.491 | 0.793 | 0.321 | 0.811 |
1037798 | HLA-DRB1*04:05 | 49 | 10 | ic50 | - | - | 0.753 | 0.899 | 0.732 | 0.877 | - | - | 0.720 | 0.821 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.684 | 0.774 | 0.564 | 0.906 |
1037798 | HLA-DRB1*07:01 | 49 | 24 | ic50 | 0.608 | 0.876 | 0.866 | 0.975 | 0.870 | 0.977 | - | - | 0.718 | 0.923 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.738 | 0.905 | 0.347 | 0.733 |
1037798 | HLA-DRB1*08:02 | 49 | 15 | ic50 | - | - | 0.583 | 0.799 | 0.679 | 0.849 | - | - | 0.807 | 0.947 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.312 | 0.665 | 0.482 | 0.771 |
1037798 | HLA-DRB1*09:01 | 49 | 23 | ic50 | 0.109 | 0.558 | 0.552 | 0.759 | 0.571 | 0.769 | - | - | 0.499 | 0.717 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.387 | 0.672 | - | - |
1037798 | HLA-DRB1*11:01 | 49 | 15 | ic50 | - | - | 0.734 | 0.976 | 0.780 | 0.984 | - | - | 0.709 | 0.931 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.716 | 0.967 | 0.517 | 0.873 |
1037798 | HLA-DRB1*12:01 | 49 | 7 | ic50 | - | - | 0.522 | 0.942 | - | - | - | - | 0.411 | 0.915 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.338 | 0.850 | - | - |
1037798 | HLA-DRB1*13:02 | 49 | 5 | ic50 | - | - | 0.606 | 0.936 | 0.516 | 0.955 | - | - | 0.480 | 0.923 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.548 | 0.836 | 0.292 | 0.636 |
1037798 | HLA-DRB1*15:01 | 49 | 31 | ic50 | - | - | 0.736 | 0.948 | 0.791 | 0.950 | - | - | 0.674 | 0.921 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.753 | 0.955 | 0.559 | 0.838 |
1037798 | HLA-DRB3*01:01 | 49 | 16 | ic50 | 0.186 | 0.605 | 0.550 | 0.843 | 0.662 | 0.888 | - | - | 0.660 | 0.869 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.508 | 0.812 | - | - |
1037798 | HLA-DRB3*02:02 | 49 | 5 | ic50 | - | - | - | - | - | - | - | - | 0.496 | 0.736 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
1037798 | HLA-DRB4*01:01 | 49 | 11 | ic50 | 0.093 | 0.555 | 0.450 | 0.798 | 0.543 | 0.821 | - | - | 0.443 | 0.737 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.439 | 0.852 | - | - |
1037798 | HLA-DRB5*01:01 | 49 | 23 | ic50 | - | - | 0.755 | 0.866 | 0.783 | 0.875 | - | - | 0.838 | 0.893 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.721 | 0.843 | 0.412 | 0.754 |
1037883 | HLA-DRB1*01:01 | 62 | 34 | binary | 0.302 | 0.678 | 0.396 | 0.733 | 0.503 | 0.792 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.251 | 0.646 | 0.364 | 0.713 |
1037883 | HLA-DRB1*04:01 | 62 | 32 | binary | - | - | 0.501 | 0.789 | 0.422 | 0.744 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.514 | 0.797 | 0.426 | 0.748 |
1037883 | HLA-DRB1*07:01 | 62 | 27 | binary | 0.414 | 0.741 | 0.678 | 0.895 | 0.606 | 0.853 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.637 | 0.871 | 0.536 | 0.815 |
1037883 | HLA-DRB1*15:01 | 62 | 22 | binary | - | - | 0.590 | 0.868 | 0.590 | 0.856 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.501 | 0.802 | 0.408 | 0.753 |
1038478 | HLA-DRB1*15:01 | 19 | 16 | binary | - | - | 0.132 | 0.604 | 0.369 | 0.792 | - | - | 0.553 | 0.938 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.237 | 0.688 | -0.106 | 0.417 |
1038237 | HLA-DRB1*01:01 | 18 | 3 | ic50 | -0.011 | 0.633 | 0.382 | 0.811 | 0.350 | 0.756 | - | - | 0.401 | 0.800 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.463 | 0.867 | 0.588 | 0.867 |
1038237 | HLA-DRB1*04:01 | 18 | 8 | ic50 | - | - | 0.366 | 0.762 | 0.245 | 0.713 | - | - | 0.197 | 0.625 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.358 | 0.725 | 0.293 | 0.738 |
1038237 | HLA-DRB1*04:05 | 18 | 6 | ic50 | - | - | 0.595 | 0.819 | 0.587 | 0.778 | - | - | 0.509 | 0.764 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.643 | 0.861 | 0.311 | 0.736 |
1038237 | HLA-DRB1*07:01 | 18 | 6 | ic50 | 0.750 | 0.861 | 0.649 | 0.854 | 0.534 | 0.889 | - | - | 0.655 | 0.889 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.680 | 0.903 | 0.541 | 0.875 |
1038237 | HLA-DRB1*08:02 | 18 | 2 | ic50 | - | - | 0.300 | 0.922 | 0.238 | 0.875 | - | - | 0.366 | 0.969 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.278 | 0.938 | 0.211 | 0.906 |
1038237 | HLA-DRB1*09:01 | 18 | 4 | ic50 | -0.367 | 0.384 | 0.540 | 0.946 | 0.581 | 1.000 | - | - | 0.534 | 0.964 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.461 | 0.964 | - | - |
1038237 | HLA-DRB1*15:01 | 18 | 8 | ic50 | - | - | 0.700 | 0.887 | 0.461 | 0.812 | - | - | 0.470 | 0.825 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.738 | 0.900 | 0.551 | 0.800 |
1038237 | HLA-DRB3*01:01 | 18 | 3 | ic50 | -0.024 | 0.578 | 0.789 | 0.989 | 0.755 | 0.956 | - | - | 0.834 | 0.889 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.888 | 1.000 | - | - |
1038237 | HLA-DRB4*01:01 | 18 | 4 | ic50 | 0.246 | 0.804 | 0.465 | 0.929 | 0.574 | 0.964 | - | - | 0.555 | 0.857 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.539 | 0.875 | - | - |