MHCII Weekly Benchmark results
Overall scores
Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.
| Server | Overall | SRCC | AUC |
|---|---|---|---|
| Comblib matrices | 10 | 10 | 10 |
| Consensus IEDB method | 64 | 67 | 61 |
| NN-align | 54 | 49 | 60 |
| NN-align 2.3 | - | - | - |
| NetMHCIIpan-3.1 | 84 | 86 | 81 |
| NetMHCIIpan-3.2 | - | - | - |
| NetMHCIIpan-4.0 BA | - | - | - |
| NetMHCIIpan-4.0 EL | - | - | - |
| NetMHCIIpan-4.1 BA | - | - | - |
| NetMHCIIpan-4.1 EL | - | - | - |
| NetMHCIIpan-4.2 BA | - | - | - |
| NetMHCIIpan-4.2 EL | - | - | - |
| NetMHCIIpan-4.3 BA | - | - | - |
| NetMHCIIpan-4.3 EL | - | - | - |
| SMM-align | 49 | 49 | 49 |
| Tepitope (Sturniolo) | 21 | 3 | 39 |
Data set specific results
Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here
Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.
| IEDB Reference |
Allele | Peptide Count |
Positive Count |
Measurement type |
Comblib matrices | Consensus IEDB method | NN-align | NN-align 2.3 | NetMHCIIpan-3.1 | NetMHCIIpan-3.2 | NetMHCIIpan-4.0 BA | NetMHCIIpan-4.0 EL | NetMHCIIpan-4.1 BA | NetMHCIIpan-4.1 EL | NetMHCIIpan-4.2 BA | NetMHCIIpan-4.2 EL | NetMHCIIpan-4.3 BA | NetMHCIIpan-4.3 EL | SMM-align | Tepitope (Sturniolo) | ||||||||||||||||
| SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | SRCC | AUC | |||||
| 1031910 | HLA-DRB1*15:01 | 28 | 23 | binary | - | - | -0.462 | 0.152 | -0.462 | 0.152 | - | - | -0.462 | 0.152 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -0.439 | 0.170 | -0.551 | 0.135 |
| 1032311 | HLA-DRB1*01:01 | 16 | 14 | ic50 | 0.038 | 0.589 | 0.297 | 0.964 | 0.276 | 0.964 | - | - | 0.432 | 1.000 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.405 | 1.000 | 0.268 | 1.000 |
| 1032520 | H2-IAb | 13 | 6 | ic50 | - | - | 0.742 | 0.810 | 0.720 | 0.810 | - | - | 0.670 | 0.857 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.621 | 0.738 | - | - |
| 1029531 | HLA-DRB1*01:01 | 11 | 4 | ic50 | 0.205 | 0.571 | 0.764 | 0.929 | 0.564 | 0.857 | - | - | 0.727 | 1.000 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.492 | 0.696 | -0.009 | 0.571 |
| 1034502 | HLA-DRB1*03:01 | 21 | 3 | ic50 | - | - | 0.313 | 0.796 | 0.419 | 0.759 | - | - | 0.595 | 0.907 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.552 | 0.870 | 0.142 | 0.611 |
| 1034502 | HLA-DRB1*08:02 | 21 | 5 | ic50 | - | - | 0.691 | 0.950 | 0.587 | 1.000 | - | - | 0.717 | 0.900 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.621 | 0.912 | 0.321 | 0.688 |
| 1034502 | HLA-DRB1*11:01 | 21 | 5 | ic50 | - | - | 0.508 | 0.863 | 0.619 | 0.825 | - | - | 0.708 | 0.912 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.532 | 0.863 | 0.301 | 0.800 |
| 1034502 | HLA-DRB1*15:01 | 21 | 4 | ic50 | - | - | 0.823 | 0.882 | 0.680 | 0.882 | - | - | 0.764 | 0.853 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.697 | 0.794 | 0.596 | 0.882 |
| 1034502 | HLA-DRB1*15:02 | 21 | 2 | ic50 | - | - | 0.581 | 0.526 | - | - | - | - | 0.728 | 0.711 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.580 | 0.605 |